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  • How Should we Diagnose Psychiatric Disorders?

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Esketamine

Esketamine for treatment-resistant depression submitted to FDA

8. September 2018/0 Comments/in Depression, Psychopharmacology /by Gerhard Gründer

Janssen Pharmaceuticals announced that the company on September 4th, 2018, submitted a New Drug Application to the US FDA for esketamine nasal spray for treatment-resistant depression.

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https://i1.wp.com/www.mind-and-brain.institute/wp-content/uploads/2018/09/Depression_1536435005.jpg?fit=1280%2C819&ssl=1 819 1280 Gerhard Gründer https://www.mind-and-brain.institute/wp-content/uploads/2017/08/MBI-Logo-Final-300x108.png Gerhard Gründer2018-09-08 21:39:382018-09-08 21:39:38Esketamine for treatment-resistant depression submitted to FDA
Schizophrenia

Should Patients with Schizophrenia be Treated with Antipsychotics Forever?

25. August 2018/0 Comments/in Antipsychotics, Schizophrenia /by Gerhard Gründer

A Finnish registry study examined the risk of rehospitalization or death in almost 9000 patients with the first episode of schizophrenia over an observation period of 20 years.

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Digital Phenotyping

“Digital Phenotyping” in German Broadcast

9. August 2018/0 Comments/in Artificial Intelligence, Big Data, Digital Phenotype /by Gerhard Gründer

A brief radio feature on “Digital Phenotyping” was broadcasted on August 8, 2018, on Deutschlandfunk.

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https://i2.wp.com/www.mind-and-brain.institute/wp-content/uploads/2018/08/Radio_1533848465.jpg?fit=1280%2C853&ssl=1 853 1280 Gerhard Gründer https://www.mind-and-brain.institute/wp-content/uploads/2017/08/MBI-Logo-Final-300x108.png Gerhard Gründer2018-08-09 23:12:332018-08-09 23:12:33"Digital Phenotyping" in German Broadcast

Big Data in Psychiatry

Big Data in Psychiatry - Brave New World?

2. August 2018
"Big Data", "Precision Medicine" and "Machine Learning" are praised as the solution of all problems in psychiatry. However, critical questions are rarely discussed.
https://i0.wp.com/www.mind-and-brain.institute/wp-content/uploads/2018/08/computer_1533237040.jpg?fit=1280%2C853&ssl=1 853 1280 Gerhard Gründer https://www.mind-and-brain.institute/wp-content/uploads/2017/08/MBI-Logo-Final-300x108.png Gerhard Gründer2018-08-02 23:08:272018-08-02 23:08:27Big Data in Psychiatry - Brave New World?
Sunrise with Cariprazine

IQWiG: Indication of an Added Benefit of Cariprazine

20. July 2018
The Institute for Quality and Efficiency in Health Care (IQWiG) on July 16, 2018, published its opinion on cariprazine as part of its „benefit assessment“. It concludes that there is an "indication" that cariprazine has a "non-quantifiable added benefit" in the group of patients with schizophrenia with predominant negative symptoms.
https://i2.wp.com/www.mind-and-brain.institute/wp-content/uploads/2018/07/Sonnenaufgang_1532117967.jpg?fit=1280%2C720&ssl=1 720 1280 Gerhard Gründer https://www.mind-and-brain.institute/wp-content/uploads/2017/08/MBI-Logo-Final-300x108.png Gerhard Gründer2018-07-20 22:52:082018-07-20 22:54:19IQWiG: Indication of an Added Benefit of Cariprazine
Withdrawal and Emotional Blunting with Chronic Antidepressant Treatment

How Common are Withdrawal and Emotional Blunting in Chronic Antidepressant Treatment?

15. July 2018
The problem of withdrawal syndromes and emotional blunting occurring with prolonged antidepressant treatment is constantly underestimated by clinicians.
https://i1.wp.com/www.mind-and-brain.institute/wp-content/uploads/2018/07/trübsinn_1531664956.jpg?fit=1280%2C850&ssl=1 850 1280 Gerhard Gründer https://www.mind-and-brain.institute/wp-content/uploads/2017/08/MBI-Logo-Final-300x108.png Gerhard Gründer2018-07-15 16:42:012018-07-15 16:42:01How Common are Withdrawal and Emotional Blunting in Chronic Antidepressant Treatment?
Crisis in Psychopharmacology

A Lecture on the "Crisis in Psychopharmacology"

7. July 2018
Lecture on "The Crisis of Psychopharmacology" at the scientific colloquium of the Department of Psychiatry and Psychotherapy of the University of Rostock.
https://i1.wp.com/www.mind-and-brain.institute/wp-content/uploads/2018/07/Crisis-in-Psychopharmacology.png?fit=2556%2C1536&ssl=1 1536 2556 Gerhard Gründer https://www.mind-and-brain.institute/wp-content/uploads/2017/08/MBI-Logo-Final-300x108.png Gerhard Gründer2018-07-07 13:45:142018-07-07 13:57:48A Lecture on the "Crisis in Psychopharmacology"
Launch Cariprazine 2018 Germany

Finally: A New Psychotropic Drug in Germany - Cariprazine

5. May 2018
Recordati launched the new antipsychotic cariprazine in Germany in Mid-April. The benefit assessment by the G-BA has therefore started.
https://i1.wp.com/www.mind-and-brain.institute/wp-content/uploads/2018/05/Medikamente__1525465583.jpg?fit=1280%2C853&ssl=1 853 1280 Gerhard Gründer https://www.mind-and-brain.institute/wp-content/uploads/2017/08/MBI-Logo-Final-300x108.png Gerhard Gründer2018-05-05 11:33:322018-05-05 12:10:29Finally: A New Psychotropic Drug in Germany - Cariprazine
Antidepressants in the New York Times

The Antidepressant Debate in the New York Times

18. April 2018
An article on the front page of the New York Times on April 7, 2018, has fueled the debate over antidepressants again.
https://i0.wp.com/www.mind-and-brain.institute/wp-content/uploads/2018/04/depression_1524081264.jpg?fit=1280%2C853&ssl=1 853 1280 Gerhard Gründer https://www.mind-and-brain.institute/wp-content/uploads/2017/08/MBI-Logo-Final-300x108.png Gerhard Gründer2018-04-18 22:03:082018-07-15 16:49:00The Antidepressant Debate in the New York Times
Summer School Psychopharmacology 2018 in Berlin

DGPPN Summer School "Psychopharmacology" 2018 in Berlin

11. April 2018
On June 28 and 29, 2018, the Summer School "Psychopharmacology", organized by the German Society for Psychiatry and Psychotherapy, Psychosomatics and Neuroscience (DGPPN), will be held in Berlin.
https://i0.wp.com/www.mind-and-brain.institute/wp-content/uploads/2018/04/Summer-School.png?fit=2404%2C1006&ssl=1 1006 2404 Gerhard Gründer https://www.mind-and-brain.institute/wp-content/uploads/2017/08/MBI-Logo-Final-300x108.png Gerhard Gründer2018-04-11 22:12:392018-04-11 22:12:39DGPPN Summer School "Psychopharmacology" 2018 in Berlin
Mental Health Crisis

The Mental Health Crisis in Graduate Education

9. April 2018
In the March issue of Nature Biotechnology, Teresa Evans of the University of San Antonio, Texas, and co-authors point out that there is "Evidence for a mental health crisis in graduate education".
https://i2.wp.com/www.mind-and-brain.institute/wp-content/uploads/2018/04/Student_1523304537.jpg?fit=1280%2C853&ssl=1 853 1280 Gerhard Gründer https://www.mind-and-brain.institute/wp-content/uploads/2017/08/MBI-Logo-Final-300x108.png Gerhard Gründer2018-04-09 22:28:082018-07-15 17:43:00The Mental Health Crisis in Graduate Education
antipsychotics long-term treatment

Antipsychotics for long-term treatment - when to stop? Or better not?

1 Comment
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2. April 2018
A new publication in the prestigious Lancet Psychiatry seems to provide new evidence for the benefits of long-term antipsychotic maintenance treatment in schizophrenia (Hui et al., Lancet Psychiatry 2018). On closer inspection, however, the paper confuses more than it provides new insights.
https://i0.wp.com/www.mind-and-brain.institute/wp-content/uploads/2018/04/psychosis_1522663879.jpg?fit=1280%2C748&ssl=1 748 1280 Gerhard Gründer https://www.mind-and-brain.institute/wp-content/uploads/2017/08/MBI-Logo-Final-300x108.png Gerhard Gründer2018-04-02 12:21:332018-04-02 12:21:33Antipsychotics for long-term treatment - when to stop? Or better not?
Gerhard Gründer at "Frag-den-Professor"

"Langzeittherapie mit Psychopharmaka" bei Frag-den-Professor

28. March 2018
My presentation on "long-term treatment with psychotropic drugs" ("Langzeittherapie mit Psychopharmaka") on the web platform "Frag-den-Professor".
https://i0.wp.com/www.mind-and-brain.institute/wp-content/uploads/2018/03/Frag-den-Professor.jpg?fit=1336%2C1026&ssl=1 1026 1336 Gerhard Gründer https://www.mind-and-brain.institute/wp-content/uploads/2017/08/MBI-Logo-Final-300x108.png Gerhard Gründer2018-03-28 23:12:242018-03-28 23:12:24"Langzeittherapie mit Psychopharmaka" bei Frag-den-Professor
Antipressants Metaanalysis

How effective are antidepressants?

1 Comment
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13. March 2018
Andrea Cipriani from the University of Oxford and colleagues have recently published the largest and most comprehensive meta-analysis of the efficacy of antidepressants in the Lancet. The paper is worth dealing with more intensively.
https://i1.wp.com/www.mind-and-brain.institute/wp-content/uploads/2018/03/medications-257333_1920.jpg?fit=1920%2C1271&ssl=1 1271 1920 Gerhard Gründer https://www.mind-and-brain.institute/wp-content/uploads/2017/08/MBI-Logo-Final-300x108.png Gerhard Gründer2018-03-13 23:05:182018-07-15 17:45:46How effective are antidepressants?
Video on Pharmacokinetics (in German)

A lecture on polypharmacy and pharmacokinetics

3. March 2018
A video of my lecture on "Polypharmacy and Pharmacokinetics", which I gave at the "Psychiatrie-Akademie" in Brugg, Switzerland on January 11th, 2018. This talk was given in German.
https://i2.wp.com/www.mind-and-brain.institute/wp-content/uploads/2018/03/PA-Brugg-Schweiz.png?fit=1740%2C944&ssl=1 944 1740 Gerhard Gründer https://www.mind-and-brain.institute/wp-content/uploads/2017/08/MBI-Logo-Final-300x108.png Gerhard Gründer2018-03-03 12:02:182018-03-19 14:06:17A lecture on polypharmacy and pharmacokinetics
Job Offer Central Institute of Mental Health

Join me me at the Central Institute of Mental Health

10. February 2018
Work with me at the Central Institute of Mental Health (CIMH) in Mannheim and build with me the future of psychiatry.
https://i0.wp.com/www.mind-and-brain.institute/wp-content/uploads/2018/02/CIMH-Job-Offer.png?fit=1994%2C1068&ssl=1 1068 1994 Gerhard Gründer https://www.mind-and-brain.institute/wp-content/uploads/2017/08/MBI-Logo-Final-300x108.png Gerhard Gründer2018-02-10 09:20:062018-02-10 09:23:21Join me me at the Central Institute of Mental Health
ACNP 2017 Palm Springs

A brief report from the 56th ACNP annual meeting

19. December 2017
The American College of Neuropsychopharmacology held its annual meeting between December 3rd and 7th, 2017, in Palm Springs, California. Here is a brief report of some of the meeting highlights.
https://i2.wp.com/www.mind-and-brain.institute/wp-content/uploads/2017/12/ACNP-2017_2.jpg?fit=1632%2C1224&ssl=1 1224 1632 Gerhard Gründer https://www.mind-and-brain.institute/wp-content/uploads/2017/08/MBI-Logo-Final-300x108.png Gerhard Gründer2017-12-19 22:33:002018-07-15 17:50:43A brief report from the 56th ACNP annual meeting
Mindme Drinks

Brainfoods has launched its first products: Mindme Drinks

19. November 2017
The company, which I founded with my sons Nikolaj and Philipp, Brainfoods GmbH, has just launched pre sales of our first three products, Mindme® Drinks.
https://i2.wp.com/www.mind-and-brain.institute/wp-content/uploads/2017/11/Mindme-6.jpg?fit=1344%2C1166&ssl=1 1166 1344 Gerhard Gründer https://www.mind-and-brain.institute/wp-content/uploads/2017/08/MBI-Logo-Final-300x108.png Gerhard Gründer2017-11-19 14:07:102017-11-19 23:47:43Brainfoods has launched its first products: Mindme Drinks

Thanks for a great time together!

12. November 2017
The staff of my unit at the Department of Psychiatry, Psychotherapy and Psychosomatics at RWTH Aachen University organized a farewell party for me.
https://i1.wp.com/www.mind-and-brain.institute/wp-content/uploads/2017/11/Farewell-2017.jpg?fit=1578%2C2374&ssl=1 2374 1578 Gerhard Gründer https://www.mind-and-brain.institute/wp-content/uploads/2017/08/MBI-Logo-Final-300x108.png Gerhard Gründer2017-11-12 14:45:042017-11-12 14:45:04Thanks for a great time together!
Robots as "Conversational Agents"

Would you talk to a machine therapist?

1. November 2017
Miner and colleagues from Stanford University believe that machine psychotherapists based on artificial intelligence could revolutionize mental health care.
https://i2.wp.com/www.mind-and-brain.institute/wp-content/uploads/2017/11/roboter_1509563270.jpg?fit=1280%2C800&ssl=1 800 1280 Gerhard Gründer https://www.mind-and-brain.institute/wp-content/uploads/2017/08/MBI-Logo-Final-300x108.png Gerhard Gründer2017-11-01 22:29:432017-11-01 22:32:55Would you talk to a machine therapist?
Man's Search for Meaning

Viktor Frankl on the Power of “Meaning” and the Conception of Psychiatry

1 Comment
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24. October 2017
Viennese psychiatrist Viktor Frankl on the power of "meaning" man has to find in life and his conception of a rehumanized psychiatry.
https://i1.wp.com/www.mind-and-brain.institute/wp-content/uploads/2017/10/Spiritualität_1508873761.jpg?fit=1280%2C853&ssl=1 853 1280 Gerhard Gründer https://www.mind-and-brain.institute/wp-content/uploads/2017/08/MBI-Logo-Final-300x108.png Gerhard Gründer2017-10-24 22:06:302017-10-24 22:33:36Viktor Frankl on the Power of “Meaning” and the Conception of Psychiatry
The foggy new paths of psychiatry

"The new paths of psychiatry" in WDR

15. October 2017
The Westdeutscher Rundfunk (WDR) on October 8th and 9th, 2017, broadcasted an interesting feature on the "new paths of psychiatry", which contains many statements I made during an interview on the future of psychopharmacology.
https://i0.wp.com/www.mind-and-brain.institute/wp-content/uploads/2017/10/Nebel_1508060924.jpg?fit=1280%2C750&ssl=1 750 1280 Gerhard Gründer https://www.mind-and-brain.institute/wp-content/uploads/2017/08/MBI-Logo-Final-300x108.png Gerhard Gründer2017-10-15 13:13:112018-07-15 17:37:17"The new paths of psychiatry" in WDR

How digital is man?

1 Comment
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7. October 2017
The former NIMH director Tom Insel believes that "digital phenotyping" moves psychiatry in a new direction.
https://i1.wp.com/www.mind-and-brain.institute/wp-content/uploads/2017/10/digital_1507391669.jpg?fit=1280%2C903&ssl=1 903 1280 Gerhard Gründer https://www.mind-and-brain.institute/wp-content/uploads/2017/08/MBI-Logo-Final-300x108.png Gerhard Gründer2017-10-07 19:43:052018-09-28 18:38:08How digital is man?
Hurdle

Cariprazine: the next touchstone for the German AMNOG

1. October 2017
The interesting new antipsychotic compound cariprazine was recently approved by the European Medicines Agency (EMA). Its launch in Germany will be a new touchstone for the German Act on the Reform of the Market for Medicinal Products (AMNOG).
https://i2.wp.com/www.mind-and-brain.institute/wp-content/uploads/2017/10/Hürde_1506861744.jpg?fit=1280%2C960&ssl=1 960 1280 Gerhard Gründer https://www.mind-and-brain.institute/wp-content/uploads/2017/08/MBI-Logo-Final-300x108.png Gerhard Gründer2017-10-01 15:45:292017-10-16 19:21:16Cariprazine: the next touchstone for the German AMNOG

Therapeutic Drug Monitoring in Neuropsychopharmacology

26. September 2017
The new "Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology: Update 2017" were just published.
https://i1.wp.com/www.mind-and-brain.institute/wp-content/uploads/2017/09/Labor_1506458207.jpg?fit=1280%2C960&ssl=1 960 1280 Gerhard Gründer https://www.mind-and-brain.institute/wp-content/uploads/2017/08/MBI-Logo-Final-300x108.png Gerhard Gründer2017-09-26 22:31:182017-10-29 19:29:25Therapeutic Drug Monitoring in Neuropsychopharmacology

How do you treat delirium?

24. September 2017
In patients with cancer and agitated delirium in palliative care, haloperidol + lorazepam was significantly more efficacious than haloperidol + placebo.
https://i1.wp.com/www.mind-and-brain.institute/wp-content/uploads/2017/09/Verwirrung_1506273347.jpg?fit=1280%2C668&ssl=1 668 1280 Gerhard Gründer https://www.mind-and-brain.institute/wp-content/uploads/2017/08/MBI-Logo-Final-300x108.png Gerhard Gründer2017-09-24 20:31:312017-10-29 19:30:44How do you treat delirium?

"Mind and Brain Blog" becomes "Mind and Brain Institute"

17. September 2017
My "Mind and Brain Blog" becomes "Mind and Brain Institute", where I will develop the utopia of a better world in the future.
https://i1.wp.com/www.mind-and-brain.institute/wp-content/uploads/2016/12/adult-1807515_1280.jpg?fit=1280%2C842&ssl=1 842 1280 Gerhard Gründer https://www.mind-and-brain.institute/wp-content/uploads/2017/08/MBI-Logo-Final-300x108.png Gerhard Gründer2017-09-17 18:40:132017-10-29 19:31:46"Mind and Brain Blog" becomes "Mind and Brain Institute"
Spirituality for Health

Does your life have purpose?

19. August 2017
Two recent articles in the prestigious JAMA journals highlight the importance of spirituality for medicine.
https://i1.wp.com/www.mind-and-brain.institute/wp-content/uploads/2017/09/Buddha_1504613794.jpg?fit=1280%2C718&ssl=1 718 1280 Gerhard Gründer https://www.mind-and-brain.institute/wp-content/uploads/2017/08/MBI-Logo-Final-300x108.png Gerhard Gründer2017-08-19 22:20:472017-10-29 19:32:25Does your life have purpose?
Top 50 Neurology Blog

Mind and Brain Blog belongs to the Top 50 Blogs in Neurology

https://i2.wp.com/www.mind-and-brain.institute/wp-content/uploads/2017/09/Neurology-transparent_1000.png?fit=1000%2C1000&ssl=1 1000 1000 Gerhard Gründer https://www.mind-and-brain.institute/wp-content/uploads/2017/08/MBI-Logo-Final-300x108.png Gerhard Gründer2017-08-13 13:35:492017-10-29 19:37:21Mind and Brain Blog belongs to the Top 50 Blogs in Neurology

One third of all cases of dementia is preventable

12. August 2017
The Lancet Commission "Dementia Prevention, Intervention and Care" suggests that one third of dementia cases can be prevented through change of lifestyle.
https://i1.wp.com/www.mind-and-brain.institute/wp-content/uploads/2017/09/Demenz_1504624934.jpg?fit=1280%2C853&ssl=1 853 1280 Gerhard Gründer https://www.mind-and-brain.institute/wp-content/uploads/2017/08/MBI-Logo-Final-300x108.png Gerhard Gründer2017-08-12 18:57:512018-07-15 18:00:52One third of all cases of dementia is preventable

Nutrition: a Mega Theme for Psychiatry of the Future

1. August 2017
A brief report from the first congress of the International Society for Nutritional Psychiatry Research (ISNPR), which emphasizes the importance of nutrition.
https://i1.wp.com/www.mind-and-brain.institute/wp-content/uploads/2017/09/Nahrung_1505938136.png?fit=1280%2C772&ssl=1 772 1280 Gerhard Gründer https://www.mind-and-brain.institute/wp-content/uploads/2017/08/MBI-Logo-Final-300x108.png Gerhard Gründer2017-08-01 14:19:042017-10-29 19:33:51Nutrition: a Mega Theme for Psychiatry of the Future

How medical education creates its own patients

28. May 2017
Two overviews in JAMA show that medical students and residents are suffering terrifyingly frequently from depression and depressive symptoms.
https://i2.wp.com/www.mind-and-brain.institute/wp-content/uploads/2017/09/arzt_1506370050.jpg?fit=1280%2C853&ssl=1 853 1280 Gerhard Gründer https://www.mind-and-brain.institute/wp-content/uploads/2017/08/MBI-Logo-Final-300x108.png Gerhard Gründer2017-05-28 11:56:272018-07-15 17:27:04How medical education creates its own patients

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Latest Blog Posts

  • How Should we Diagnose Psychiatric Disorders?8. November 2018 - 23:48
  • EsketamineEsketamine for treatment-resistant depression submitted to FDA8. September 2018 - 21:39
  • SchizophreniaShould Patients with Schizophrenia be Treated with Antipsychotics Forever?25. August 2018 - 13:27
  • Digital Phenotyping“Digital Phenotyping” in German Broadcast9. August 2018 - 23:12
  • Big Data in PsychiatryBig Data in Psychiatry – Brave New World?2. August 2018 - 23:08
  • Sunrise with CariprazineIQWiG: Indication of an Added Benefit of Cariprazine20. July 2018 - 22:52
  • Withdrawal and Emotional Blunting with Chronic Antidepressant TreatmentHow Common are Withdrawal and Emotional Blunting in Chronic Antidepressant Treatment?15. July 2018 - 16:42
  • Crisis in PsychopharmacologyA Lecture on the “Crisis in Psychopharmacology”7. July 2018 - 13:45
Top 50 Neurology Blog

Top Posts & Pages

  • Finally: A New Psychotropic Drug in Germany - Cariprazine
  • Viktor Frankl on the Power of “Meaning” and the Conception of Psychiatry
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